解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::For cardiovascular biomaterials, thrombosis, thromboembolism and vascular graft occlusion are believed to be precipitated by the adsorption of proteins containing adhesive ligands for platelets. Polyethylene-glycol-diisocyanate (PEG-diisocyanate, 3400 MW) may potentially react with protein amines to form molecular bar...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00098-2
更新日期:1998-10-01 00:00:00
abstract::Efficacy of different chemical treatments on calcification of vascular graft in vitro and in vivo was studied. Culture medium-filled rat aortas were separately treated in 0.2% glutaraldehyde and epoxy compound, and photooxidized in 0.01% methylene blue for a shorter period (group 1). Another group of rat aortas were s...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00038-6
更新日期:1998-09-01 00:00:00
abstract::Local contact stresses at the bone-cement interface are thought to play an important role in the initiation of component loosening. A reduced-modulus bone cement can lower these local contact stresses. The viscoelastic properties of such a cement raised the question of long term subsidence of the implant system. In th...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00115-4
更新日期:1998-09-01 00:00:00
abstract::Arterial catheterization is one of the most frequently performed inpatient diagnostic and therapeutic procedures in the development countries. Complications may occur after any catheterization from inadequate hemostasis, particularly in the setting of aggressive anticoagulation. This study suggests that microcrystalli...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00060-x
更新日期:1998-08-01 00:00:00
abstract::In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00070-2
更新日期:1998-08-01 00:00:00
abstract::Neonatal rat calvarial osteoblasts were cultured in 90% porous, 75:25 poly(DL-lactic-co-glycolic acid) (PLGA) foam scaffolds for up to 56 days to examine the effects of the cell seeding density, scaffold pore size, and foam thickness on the proliferation and function of the cells in this three-dimensional environment....
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00021-0
更新日期:1998-08-01 00:00:00
abstract::The formation of bone tissue in pores, and around, a block made of partially dehydroxylated porous hydroxyapatite ceramic and implanted into a rat's femur using X-ray diffraction (XRD), infrared spectroscopy (IRS) and histological methods were investigated. Structural characteristics and composition of new bone tissue...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00024-6
更新日期:1998-07-01 00:00:00
abstract::The stabilities of two types of polymerically stabilized liposomes consisting of PEG-grafted (DSPC:CHOL:DSPE-PEG1900, 5:4:1) and physically adsorbed carboxymethylchitin (CMC) and carboxymethyl/glycolchitin (CO) are compared. The polyelectrolyte is adsorbed on positive (DSPC:CHOL:DMTAP, 5:4:1) and neutral (DSPC:CHOL, 1...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00004-0
更新日期:1998-07-01 00:00:00
abstract::Two new formulations of bioactive glasses were used as coatings on titanium alloy (TiAl6V4) implants for prosthetic applications in the orthopaedic field. The biocompatibility of these bioglasses, as well as their osteoconductive properties, were assessed by employing primary cultures of human osteoblasts. A nonbioact...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00249-4
更新日期:1998-06-01 00:00:00
abstract::To evaluate whether cytokeratin expression in human oral epithelial cells could be influenced by implant materials used in dental surgery, passaged human oral gingival epithelial cells were seeded on commercially pure titanium (CP-Ti) or on Ti6Al4V titanium alloy. Confluence was achieved after about 15 days on both su...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00041-6
更新日期:1998-06-01 00:00:00
abstract::The aim of this study, in rabbit tibia, was an evaluation of the early reactions of the tissues to the insertion of polylactic membranes, used in connection with titanium implants. The specimens were retrieved after 1-4 weeks, and a histological analysis was performed. It was possible to see that, in the early implant...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00173-7
更新日期:1998-05-01 00:00:00
abstract::The aim of this study was to evaluate the bacterial adherence to biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA 96) spiral stents in vitro. They are used as temporary urethral stents in urology. Gold-plated metal wire, polyurethane and latex were used as contro...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00171-3
更新日期:1998-04-01 00:00:00
abstract::Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neopla...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00209-3
更新日期:1998-04-01 00:00:00
abstract::Microencapsulation of dopamine-secreting cells in biocompatible, semi-permeable polymer membranes has been proposed as an alternative strategy for dopamine replacement for Parkinson's disease. In order to assess the viability of this proposal, dopamine-secreting PC12 cells were immunoisolated via microencapsulation in...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00241-x
更新日期:1998-04-01 00:00:00
abstract::Immediate finishing is a highly desirable property of restorative materials. In general, the resin composites, the polyacid-modified resin composites and resin-modified glass-ionomers are finished immediately after light-curing. For the conventional glass-ionomers a waiting period of 24 h is recommended. Therefore, th...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00134-8
更新日期:1998-03-01 00:00:00
abstract::It is now well accepted that the initial rapid adsorption of blood proteins to biomaterial surfaces is important in the long-term performance of the implant. Cells that interact with the implant will be reacting to a layer (single or multiple) of adsorbed protein. The parameters of importance in a study of protein ads...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00223-8
更新日期:1998-03-01 00:00:00
abstract::A total of 60 cylindrical 6 x 6 mm samples of a macroporous biphasic calcium phosphate (MBCP) ceramic were implanted into a distal femoral site in 30 rabbits. These samples represented six kinds of implants with two different macropore diameters and three different macroporosity percentages. Analysis of backscattered ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00180-4
更新日期:1998-01-01 00:00:00
abstract::Boiling diluted alkali incubation was found to be an effective way to prepare bioactive Ti6Al4V surfaces, whether polished or not, as indicated in vitro after immersion in two different supersaturated calcification solutions (SCSs). The induction of calcium phosphate (Ca-P) precipitation from the SCSs is most probably...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00232-9
更新日期:1998-01-01 00:00:00
abstract::Silicone elastomers have been used as implants in orthopaedics for replacements of small joints such as the metacarpophalangeal joint. A series of experiments was conducted an axially tensioned silicone elastomer tendon spacer samples to determine whether there is a relationship between stress in the material and imag...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00155-5
更新日期:1998-01-01 00:00:00
abstract::A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phos...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)80009-9
更新日期:1997-12-01 00:00:00
abstract::The interaction of three cell types important to the wound repair process with collagen/glycosaminoglycan (GAG) dermal regeneration matrices covalently modified with an Arg-Gly-Asp (RGD)-containing peptide was characterized. Function-blocking monoclonal antibodies directed against various integrin subunits were used t...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00103-8
更新日期:1997-12-01 00:00:00
abstract::The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00076-8
更新日期:1997-11-01 00:00:00
abstract::The efficacy of colloidal particles as drug carriers is closely related to their interaction with proteins and enzymes in different body fluids. In the present work, we analysed the interaction phenomenon between lysozyme (LZM), a positively charged enzyme that is highly concentrated in mucosas, and two different drug...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00061-6
更新日期:1997-10-01 00:00:00
abstract::The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00045-8
更新日期:1997-09-01 00:00:00
abstract::We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00064-1
更新日期:1997-09-01 00:00:00
abstract::The adsorption of chondroitin-4-sulphate (C4S) and heparin onto titanium has been studied in the absence and presence of bovine serum albumin (BSA). Isotherm data (0.02 M calcium acetate, pH 6.8) have shown that BSA in solution and BSA-coated titanium result in decreased adsorption for both C4S and heparin. For the BS...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00044-6
更新日期:1997-08-01 00:00:00
abstract::In order to evaluate degradation kinetics and biocompatibility of a resorbable poly(D,L-lactic acid) (PDLLA) plug for total cemented hip prostheses, an experimental in vitro and in vivo study was carried out. Degradation rate studies were performed in Ringer solution and after in vivo plug implantation in the femoral ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00014-8
更新日期:1997-07-01 00:00:00
abstract::This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00201-3
更新日期:1997-07-01 00:00:00
abstract::Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00007-0
更新日期:1997-06-01 00:00:00
abstract::A new thiolating reagent is used to introduce sulphur groups into denatured atelocollagen. The procedure is easy to control and applicable on a large scale. The reagent is a reactive dicarboxylic acid compound containing sulphur in the form of a disulphide functionality. It is prepared by reacting N,N'-disuccinoylcyst...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(97)00002-1
更新日期:1997-06-01 00:00:00
abstract::After surgery, the bone and soft tissues around integrated biomaterials can be adversely affected by implant-related factors acting over a period of years. However, few studies have directly addressed the effects upon the adjacent soft tissue. The present study was designed to test the biological effects of various si...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00183-4
更新日期:1997-05-01 00:00:00
abstract::Hydrogels based on ethoxytriethyleneglycol monomethacrylate/methyl methacrylate copolymers were prepared by free radical polymerization at 70 degrees C in bulk with 2,2'-azobisisobutyronitrile as initiator. The swelling behaviour of the hydrogels was studied by immersion of the films in water and in buffered solutions...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00091-9
更新日期:1997-04-01 00:00:00
abstract::This study was undertaken to evaluate the influence of storage conditions on the shelf-life of porcine bioprosthetic valves. Fifty-five unimplanted porcine bioprostheses have been evaluated. The valves were stored in 0.5% buffered glutaraldehyde solution for different periods of time (7, 23 and 32 months). Twenty-eigh...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00155-x
更新日期:1997-04-01 00:00:00
abstract::The erosion of composite polymer matrices made of slow and fast eroding polymers was investigated. These matrices can be used as implants that release drugs in a preprogrammed way. To understand the mechanism of drug release, the erosion of cylindrical polymer matrices made of several layers of different polymers was ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00151-2
更新日期:1997-03-01 00:00:00
abstract::Calcium phosphate ceramics used for clinical applications vary considerably in their phase composition. A range of hydroxyapatite and tricalcium phosphate powders, some of which are used in plasma-sprayed coatings for metal prostheses, were found to leach substances which change the pH of water and cell culture medium...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00157-3
更新日期:1997-03-01 00:00:00
abstract::The objective of the study was to examine the effect of alkali ion release, pH control and buffer capacity on the expression of the osteoblastic phenotype. In addition we determined the importance of modifications of the surface of porous bioactive glass (BG) on the activity of rat calvaria osteoblasts in vitro. We fo...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00059-2
更新日期:1997-02-01 00:00:00
abstract::PVA-AA, an esterification product of poly(vinyl alcohol) and acryloyl chloride, was synthesized and tested for its dentine bonding ability as an additive to 2-hydroxyethyl methacrylate (HEMA). The dentine bonding strength increased significantly by increasing the concentration of PVA-AA in HEMA. The dentine tensile bo...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00142-1
更新日期:1997-02-01 00:00:00
abstract::The kinetics of thrombin inhibition by antithrombin (AT) and heparin cofactor II (HC II) were analysed as a function of the heparin concentration, from 10(-9) to 10(-4) M. The initial concentrations of inhibitor (l) and thrombin (E) were set at equimolar levels (CI = CE = 10(-8) M). The experimental data indicate that...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00125-1
更新日期:1997-02-01 00:00:00
abstract::Alginate-polylysine (PLL) capsules are commonly applied for immunoprotection of endocrine tissues. Alginate is composed of mannuronic acid (M) and guluronic acid (G). Different types of alginate have different ratios of G to M, but little is known of the influence of these differences on biocompatibility. Therefore, w...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00135-4
更新日期:1997-02-01 00:00:00
abstract::The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(96)00094-4
更新日期:1997-01-01 00:00:00